It is generally considered safe to use both Flonase and azelastine for the treatment of your allergic rhinitis. Your healthcare provider may recommend this or prescribe you Dymista (azelastine hydrochloride and fluticasone propionate), a nasal spray composed of generic forms of both medications.
How the Medications Compare
Flonase is a nasal steroid that works by reducing inflammation, a major component of allergic reactions.
Fluticasone propionate, the generic of Flonase, is also sold in another formulation, called Xhance, by prescription only for patients with chronic rhinosinusitis.
Flonase can cause side effects, including:
Nosebleeds or nose tendernessHeadachesSore throatNauseaCough
Azelastine is an antihistamine, which works by suppressing histamine—a protein that triggers the symptoms of an allergic reaction.
Only generic azelastine is available by prescription, as the brand Astelin has been discontinued in the U.S. However, Astepro (azelastine 0.15%) nasal spray has been approved for nonprescription use in those 6 years and older. Azelastine 0.1% remains a prescription medication for younger children.
This type of nasal spray can cause:
Bitter tasteHeadachesDrowsinessTinglingNasal burningSore throatSinusitisBloody noseSneezing episodesNauseaDizzinessWeight gain
Combining Flonase and Azelastine
Using Flonase with azelastine is considered a second-line option, which means that the combined treatment approach is only used when you don’t experience adequate improvement of your symptoms with use of just one of these sprays.
Whether or not that level of treatment is necessary to tame your symptoms depends, in part, on the severity of your allergies. Symptoms are generally so bothersome and noticeable that you should be able to judge your response to treatment well.
Combining Flonase and azelastine is considered safe and does not add to side effects outlined for each medication.
Dymista
Combination medications like Dymista include more than one medication. The advantage of this type of treatment is that it is faster and more convenient to get more than one ingredient at once than to take them separately.
The disadvantage is that you get a fixed dose of each component, so you and your healthcare provider can’t make adjustments to one drug without affecting the other. Also, this medication is sometimes not covered by insurance.
If your healthcare provider prescribes Dymista, you would also take it on a schedule to prevent your symptoms from happening.
Dymista nasal spray suspension delivers 137 mcg of azelastine hydrochloride and 50 mcg of fluticasone propionate (137 mcg/50 mcg) in each 0.137 mL spray. The recommended dose is one spray per nostril twice daily.
The most common side effects of Dymista, as reported by the manufacturer, are:
Distorted sense of taste (dysgeusia) Headaches Bloody nose (epistaxis)
This medication can also cause sleepiness or drowsiness, so you need to be careful about driving or using heavy machinery.
A Word From Verywell
There are a number of treatments for allergic rhinitis, including nasal steroids, oral or nasal antihistamines, leukotriene inhibitors, and allergy shots. It’s not uncommon to combine different medications when trying to reduce symptoms of allergic rhinitis, but combining treatments has to be done safely to avoid drug interactions and harmful side effects.
If you feel that your current regimen is not providing you adequate relief, speak with your healthcare provider.
